Drug interactions
Influenza virus vaccine trivalent adjuvanted + Temsirolimus
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus may reduce the antibody response to inactivated influenza vaccine, so protection may be inadequate. The vaccine is non-live and vaccination is still generally recommended in cancer patients.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression by mTOR inhibition reduces vaccine-induced immune responses.
What to do
Do not withhold the annual vaccine; ideally vaccinate before starting therapy, and maintain other protective measures during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Temsirolimus?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus may reduce the antibody response to inactivated influenza vaccine, so protection may be inadequate. The vaccine is non-live and vaccination is still generally recommended in cancer patients.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the annual vaccine; ideally vaccinate before starting therapy, and maintain other protective measures during treatment.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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