Drug interactions
Inotuzumab + Sotalol
Severity: Major
Inotuzumab and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin can prolong the QT interval, and sotalol has a strong risk of torsades de pointes. Together they may increase the probability of serious ventricular arrhythmia.
What this interaction means in plain words
Inotuzumab and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Avoid if an alternative exists; otherwise obtain ECGs and electrolytes before starting and periodically afterward, correcting abnormalities promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Inotuzumab with Sotalol?
MediHelp rates the interaction as major. Inotuzumab and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin can prolong the QT interval, and sotalol has a strong risk of torsades de pointes. Together they may increase the probability of serious ventricular arrhythmia.
How serious is the interaction between Inotuzumab and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; otherwise obtain ECGs and electrolytes before starting and periodically afterward, correcting abnormalities promptly.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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