Drug interactions
Insulin aspart + Linagliptin
Severity: Moderate
Insulin aspart and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin enhances glucose-dependent insulin release and lowers glucagon, so adding it to insulin can increase hypoglycemia risk. The risk is modest but present.
What this interaction means in plain words
Insulin aspart and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and DPP-4 inhibition raising incretin levels.
What to do
Monitor blood glucose when starting linagliptin and consider a lower insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin aspart with Linagliptin?
MediHelp rates the interaction as moderate. Insulin aspart and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin enhances glucose-dependent insulin release and lowers glucagon, so adding it to insulin can increase hypoglycemia risk. The risk is modest but present.
How serious is the interaction between Insulin aspart and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting linagliptin and consider a lower insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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