Drug interactions
Insulin aspart protamine / insulin aspart + Linagliptin
Severity: Moderate
Insulin aspart protamine / insulin aspart and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin enhances glucose lowering and increases the risk of hypoglycemia. The combination is widely used and effective but may require a lower insulin dose.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering: DPP-4 inhibition raises incretin-driven insulin secretion and suppresses glucagon while exogenous insulin lowers glucose directly.
What to do
Monitor blood glucose and consider reducing the insulin dose when starting linagliptin; educate the patient about hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Linagliptin?
MediHelp rates the interaction as moderate. Insulin aspart protamine / insulin aspart and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to insulin enhances glucose lowering and increases the risk of hypoglycemia. The combination is widely used and effective but may require a lower insulin dose.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider reducing the insulin dose when starting linagliptin; educate the patient about hypoglycemia.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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