Drug interactions
Insulin degludec + Labetalol
Severity: Moderate
Insulin degludec and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and tachycardia, and may delay glucose recovery. They can also alter glycemic control in either direction.
What this interaction means in plain words
Insulin degludec and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Labetalol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade impairs glycogenolysis and counter-regulation and masks hypoglycemia symptoms.
What to do
Monitor blood glucose more frequently, especially when starting or changing the beta-blocker. Educate patients that sweating may remain while other hypoglycemia symptoms are masked.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Labetalol?
MediHelp rates the interaction as moderate. Insulin degludec and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and tachycardia, and may delay glucose recovery. They can also alter glycemic control in either direction.
How serious is the interaction between Insulin degludec and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently, especially when starting or changing the beta-blocker. Educate patients that sweating may remain while other hypoglycemia symptoms are masked.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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