Drug interactions
Insulin degludec + Liraglutide
Severity: Moderate
Insulin degludec and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. The combination is therapeutic but usually needs an insulin dose reduction.
What this interaction means in plain words
Insulin degludec and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
GLP-1 receptor agonism increases glucose-dependent insulin secretion and suppresses glucagon, adding to exogenous insulin.
What to do
Monitor blood glucose when starting liraglutide and consider reducing the insulin degludec dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin degludec with Liraglutide?
MediHelp rates the interaction as moderate. Insulin degludec and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. The combination is therapeutic but usually needs an insulin dose reduction.
How serious is the interaction between Insulin degludec and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting liraglutide and consider reducing the insulin degludec dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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