Drug interactions
Insulin degludec + Lurasidone
Severity: Moderate
Insulin degludec and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can worsen glycemic control and may reduce the effect of insulin. Lurasidone has relatively low metabolic liability, but glucose may still rise in diabetic patients.
What this interaction means in plain words
Insulin degludec and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-associated insulin resistance and altered glucose regulation oppose insulin action.
What to do
Monitor blood glucose more frequently after starting or changing lurasidone and titrate the insulin degludec dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Lurasidone?
MediHelp rates the interaction as moderate. Insulin degludec and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can worsen glycemic control and may reduce the effect of insulin. Lurasidone has relatively low metabolic liability, but glucose may still rise in diabetic patients.
How serious is the interaction between Insulin degludec and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting or changing lurasidone and titrate the insulin degludec dose accordingly.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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