Drug interactions
Insulin degludec + Macimorelin
Severity: Minor
Insulin degludec and Macimorelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin is used to test for adult growth hormone deficiency, and insulin-induced hypoglycemia is itself a growth hormone stimulus. Insulin could therefore alter the test result, although exogenous insulin is not a labeled interferent in the way that other GH-affecting drugs are.
What this interaction means in plain words
Insulin degludec and Macimorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Macimorelin belongs to Endocrine.
Why it happens
Insulin-induced hypoglycemia can transiently raise growth hormone, which may confound the stimulation test; the effect is indirect.
What to do
Ensure glucose is stable and avoid hypoglycemia around the test. Follow macimorelin labeling for fasting and washout of drugs that affect GH.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Other interactions of Macimorelin
Frequently asked questions
Can I take Insulin degludec with Macimorelin?
MediHelp rates the interaction as minor. Insulin degludec and Macimorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macimorelin is used to test for adult growth hormone deficiency, and insulin-induced hypoglycemia is itself a growth hormone stimulus. Insulin could therefore alter the test result, although exogenous insulin is not a labeled interferent in the way that other GH-affecting drugs are.
How serious is the interaction between Insulin degludec and Macimorelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure glucose is stable and avoid hypoglycemia around the test. Follow macimorelin labeling for fasting and washout of drugs that affect GH.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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