Drug interactions
Insulin degludec + Metoprolol
Severity: Moderate
Insulin degludec and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations and may delay glucose recovery. They can also alter glycemic control in either direction. Sweating is usually preserved.
What this interaction means in plain words
Insulin degludec and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Metoprolol belongs to Cardiovascular.
Why it happens
Beta-blockade blunts adrenergic hypoglycemia symptoms and glycogenolytic recovery, and can also impair insulin secretion.
What to do
Monitor blood glucose more frequently when starting or changing the beta-blocker and educate the patient about masked hypoglycemia symptoms. Adjust the insulin dose based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Metoprolol?
MediHelp rates the interaction as moderate. Insulin degludec and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask adrenergic warning symptoms of hypoglycemia such as tremor and palpitations and may delay glucose recovery. They can also alter glycemic control in either direction. Sweating is usually preserved.
How serious is the interaction between Insulin degludec and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing the beta-blocker and educate the patient about masked hypoglycemia symptoms. Adjust the insulin dose based on readings.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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