Drug interactions
Insulin degludec + Norethisterone
Severity: Minor
Insulin degludec and Norethisterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of insulin. The effect is generally small with norethisterone but may matter in poorly controlled diabetes.
What this interaction means in plain words
Insulin degludec and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Norethisterone belongs to Endocrine.
Why it happens
Progestogenic effects can reduce insulin sensitivity, opposing the action of insulin.
What to do
Monitor blood glucose when starting or stopping norethisterone and adjust the insulin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Norethisterone?
MediHelp rates the interaction as minor. Insulin degludec and Norethisterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of insulin. The effect is generally small with norethisterone but may matter in poorly controlled diabetes.
How serious is the interaction between Insulin degludec and Norethisterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping norethisterone and adjust the insulin dose if needed.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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