Drug interactions
Insulin degludec + Perphenazine
Severity: Moderate
Insulin degludec and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can alter glucose regulation and may raise blood glucose, reducing the effectiveness of insulin. Glycemic control can worsen when perphenazine is started, and hypoglycemia may occur if it is later stopped without insulin adjustment.
What this interaction means in plain words
Insulin degludec and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism, as phenothiazines may impair glucose tolerance and insulin sensitivity.
What to do
Monitor blood glucose more frequently after starting, changing or stopping perphenazine. Adjust the insulin degludec dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Perphenazine?
MediHelp rates the interaction as moderate. Insulin degludec and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can alter glucose regulation and may raise blood glucose, reducing the effectiveness of insulin. Glycemic control can worsen when perphenazine is started, and hypoglycemia may occur if it is later stopped without insulin adjustment.
How serious is the interaction between Insulin degludec and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting, changing or stopping perphenazine. Adjust the insulin degludec dose as needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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