Drug interactions
Insulin degludec + Testosterone
Severity: Minor
Insulin degludec and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may improve insulin sensitivity and lower blood glucose, potentially adding to the effect of insulin degludec. Hypoglycemia is possible, particularly when androgen therapy is started.
What this interaction means in plain words
Insulin degludec and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Androgens may enhance insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Monitor blood glucose when starting or changing testosterone. Reduce the insulin dose if glucose levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Insulin degludec with Testosterone?
MediHelp rates the interaction as minor. Insulin degludec and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may improve insulin sensitivity and lower blood glucose, potentially adding to the effect of insulin degludec. Hypoglycemia is possible, particularly when androgen therapy is started.
How serious is the interaction between Insulin degludec and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing testosterone. Reduce the insulin dose if glucose levels fall.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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