Drug interactions
Insulin degludec-insulin aspart + Lithium
Severity: Minor
Insulin degludec-insulin aspart and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can alter glucose metabolism, and glycemic effects in patients on insulin are inconsistent, with either hypoglycemia or hyperglycemia reported. The clinical effect is usually modest but can change insulin requirements.
What this interaction means in plain words
Insulin degludec-insulin aspart and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-insulin aspart belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Lithium has variable effects on insulin secretion and sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when lithium is started, changed or stopped, and adjust insulin doses if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Lithium?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium can alter glucose metabolism, and glycemic effects in patients on insulin are inconsistent, with either hypoglycemia or hyperglycemia reported. The clinical effect is usually modest but can change insulin requirements.
How serious is the interaction between Insulin degludec-insulin aspart and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lithium is started, changed or stopped, and adjust insulin doses if control changes.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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