Drug interactions
Insulin degludec-insulin aspart + Lonapegsomatropin
Severity: Moderate
Insulin degludec-insulin aspart and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone therapy can reduce insulin sensitivity, which may raise blood glucose in people with diabetes. Insulin requirements may increase, particularly at higher growth hormone doses.
What this interaction means in plain words
Insulin degludec-insulin aspart and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone causes pharmacodynamic antagonism of insulin by promoting insulin resistance and reducing peripheral glucose uptake.
What to do
Monitor blood glucose more often when starting, changing or stopping lonapegsomatropin. Adjust insulin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone therapy can reduce insulin sensitivity, which may raise blood glucose in people with diabetes. Insulin requirements may increase, particularly at higher growth hormone doses.
How serious is the interaction between Insulin degludec-insulin aspart and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting, changing or stopping lonapegsomatropin. Adjust insulin doses as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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