Drug interactions
Insulin degludec-insulin aspart + Octreotide
Severity: Moderate
Insulin degludec-insulin aspart and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide alters glucose homeostasis by suppressing insulin, glucagon and growth hormone secretion. In insulin-treated patients it can produce either hypoglycemia or hyperglycemia, and insulin requirements may change unpredictably, especially at initiation or dose change.
What this interaction means in plain words
Insulin degludec-insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Octreotide inhibits secretion of insulin, glucagon and growth hormone, producing pharmacodynamic effects on glucose that are variable.
What to do
Monitor blood glucose more frequently when octreotide is started, changed or stopped. Adjust insulin doses according to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Octreotide?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide alters glucose homeostasis by suppressing insulin, glucagon and growth hormone secretion. In insulin-treated patients it can produce either hypoglycemia or hyperglycemia, and insulin requirements may change unpredictably, especially at initiation or dose change.
How serious is the interaction between Insulin degludec-insulin aspart and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when octreotide is started, changed or stopped. Adjust insulin doses according to readings.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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