Drug interactions
Insulin degludec-insulin aspart + Olanzapine
Severity: Moderate
Insulin degludec-insulin aspart and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause weight gain, insulin resistance and hyperglycemia, which may reduce the effectiveness of insulin therapy. Diabetic patients may need higher insulin doses and closer glucose control.
What this interaction means in plain words
Insulin degludec-insulin aspart and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine promotes insulin resistance and metabolic disturbance, opposing the glucose-lowering effect of insulin.
What to do
Check blood glucose and HbA1c more often when starting or changing olanzapine and titrate insulin as required. Consider a less metabolically active antipsychotic if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Olanzapine?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause weight gain, insulin resistance and hyperglycemia, which may reduce the effectiveness of insulin therapy. Diabetic patients may need higher insulin doses and closer glucose control.
How serious is the interaction between Insulin degludec-insulin aspart and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose and HbA1c more often when starting or changing olanzapine and titrate insulin as required. Consider a less metabolically active antipsychotic if control worsens.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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