Drug interactions
Insulin degludec-insulin aspart + Penbutolol
Severity: Moderate
Insulin degludec-insulin aspart and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask the adrenergic warning symptoms of hypoglycemia such as tremor and tachycardia, and may prolong recovery from low blood glucose. Non-selective agents can also impair glycemic control in some patients. Sweating may be preserved while other warning signs are blunted.
What this interaction means in plain words
Insulin degludec-insulin aspart and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade impairs catecholamine-mediated glycogenolysis and masks sympathetic hypoglycemia symptoms, with possible reduction of insulin secretion.
What to do
Monitor blood glucose more frequently, especially after starting or changing the beta-blocker, and educate the patient that hypoglycemia may present with few warning signs. Adjust insulin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Penbutolol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask the adrenergic warning symptoms of hypoglycemia such as tremor and tachycardia, and may prolong recovery from low blood glucose. Non-selective agents can also impair glycemic control in some patients. Sweating may be preserved while other warning signs are blunted.
How serious is the interaction between Insulin degludec-insulin aspart and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently, especially after starting or changing the beta-blocker, and educate the patient that hypoglycemia may present with few warning signs. Adjust insulin doses as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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