Drug interactions
Insulin degludec-insulin aspart + Phenylephrine
Severity: Minor
Insulin degludec-insulin aspart and Phenylephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic phenylephrine may raise blood glucose and modestly reduce the effect of insulin. The effect is usually small and short-lived with typical doses.
What this interaction means in plain words
Insulin degludec-insulin aspart and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-insulin aspart belongs to Endocrine; Phenylephrine belongs to Respiratory.
Why it happens
Adrenergic stimulation promotes hepatic glucose production and glycogenolysis and reduces insulin secretion.
What to do
Monitor blood glucose when systemic phenylephrine is used repeatedly or at high doses, and adjust insulin if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Phenylephrine?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic phenylephrine may raise blood glucose and modestly reduce the effect of insulin. The effect is usually small and short-lived with typical doses.
How serious is the interaction between Insulin degludec-insulin aspart and Phenylephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when systemic phenylephrine is used repeatedly or at high doses, and adjust insulin if needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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