Drug interactions
Insulin degludec-insulin aspart + Progesterone intravaginal
Severity: Minor
Insulin degludec-insulin aspart and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can impair glucose tolerance, but vaginal progesterone has limited systemic exposure. Any effect on insulin requirements is likely small.
What this interaction means in plain words
Insulin degludec-insulin aspart and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogens may reduce insulin sensitivity through pharmacodynamic antagonism.
What to do
Monitor blood glucose routinely when starting or stopping therapy. Adjust the insulin dose only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Progesterone intravaginal?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can impair glucose tolerance, but vaginal progesterone has limited systemic exposure. Any effect on insulin requirements is likely small.
How serious is the interaction between Insulin degludec-insulin aspart and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose routinely when starting or stopping therapy. Adjust the insulin dose only if control changes.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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