Drug interactions
Insulin degludec-insulin aspart + Propranolol
Severity: Moderate
Insulin degludec-insulin aspart and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol, a nonselective beta-blocker, can mask hypoglycemia symptoms such as tremor and tachycardia, and may prolong recovery from low glucose. This increases the risk of unrecognized or severe hypoglycemia in insulin users.
What this interaction means in plain words
Insulin degludec-insulin aspart and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Nonselective beta blockade masks adrenergic symptoms and impairs glycogenolysis and counter-regulation.
What to do
Monitor glucose frequently and educate the patient that sweating may be the only warning sign. Consider a cardioselective agent if a beta-blocker is needed and adjust insulin as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-insulin aspart and Propranolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Propranolol?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol, a nonselective beta-blocker, can mask hypoglycemia symptoms such as tremor and tachycardia, and may prolong recovery from low glucose. This increases the risk of unrecognized or severe hypoglycemia in insulin users.
How serious is the interaction between Insulin degludec-insulin aspart and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and educate the patient that sweating may be the only warning sign. Consider a cardioselective agent if a beta-blocker is needed and adjust insulin as required.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
