Drug interactions
Insulin degludec-insulin aspart + Quinapril
Severity: Moderate
Insulin degludec-insulin aspart and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin. This can increase hypoglycemia risk, particularly soon after starting the ACE inhibitor.
What this interaction means in plain words
Insulin degludec-insulin aspart and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition may improve insulin sensitivity and glucose uptake, adding to insulin's effect.
What to do
Monitor blood glucose when starting or adjusting quinapril and warn patients about hypoglycemia symptoms. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Quinapril?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and may enhance the glucose-lowering effect of insulin. This can increase hypoglycemia risk, particularly soon after starting the ACE inhibitor.
How serious is the interaction between Insulin degludec-insulin aspart and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting quinapril and warn patients about hypoglycemia symptoms. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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