Drug interactions
Insulin degludec / insulin aspart + Risperidone
Severity: Moderate
Insulin degludec / insulin aspart and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and weight gain, which may reduce the glucose-lowering effect of insulin. Insulin requirements may rise and glycemic control can worsen.
What this interaction means in plain words
Insulin degludec / insulin aspart and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects that oppose insulin action.
What to do
Monitor blood glucose more often when starting or changing risperidone. Adjust the insulin dose to maintain glycemic targets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Risperidone?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and weight gain, which may reduce the glucose-lowering effect of insulin. Insulin requirements may rise and glycemic control can worsen.
How serious is the interaction between Insulin degludec / insulin aspart and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or changing risperidone. Adjust the insulin dose to maintain glycemic targets.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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