Drug interactions
Insulin degludec-insulin aspart + Somatropin
Severity: Moderate
Insulin degludec-insulin aspart and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin reduces insulin sensitivity and can raise blood glucose, so insulin requirements may increase after starting growth hormone. Diabetes control may worsen, especially at higher doses.
What this interaction means in plain words
Insulin degludec-insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases lipolysis and hepatic glucose output, opposing insulin action.
What to do
Monitor glucose closely after starting or changing the somatropin dose and increase insulin as required. Reduce insulin if growth hormone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Somatropin?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin reduces insulin sensitivity and can raise blood glucose, so insulin requirements may increase after starting growth hormone. Diabetes control may worsen, especially at higher doses.
How serious is the interaction between Insulin degludec-insulin aspart and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely after starting or changing the somatropin dose and increase insulin as required. Reduce insulin if growth hormone is stopped.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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