Drug interactions
Insulin degludec / insulin aspart + Sotalol
Severity: Moderate
Insulin degludec / insulin aspart and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers like sotalol can mask the adrenergic warning signs of hypoglycemia, such as tremor and tachycardia, and can prolong recovery from hypoglycemia. They can also alter glycemic control.
What this interaction means in plain words
Insulin degludec / insulin aspart and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-blockade blunts adrenergic hypoglycemia symptoms and impairs glycogenolysis and counter-regulation.
What to do
Advise patients to monitor blood glucose more frequently, particularly after starting or changing sotalol, and teach them that sweating may be the only warning sign of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Sotalol?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers like sotalol can mask the adrenergic warning signs of hypoglycemia, such as tremor and tachycardia, and can prolong recovery from hypoglycemia. They can also alter glycemic control.
How serious is the interaction between Insulin degludec / insulin aspart and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to monitor blood glucose more frequently, particularly after starting or changing sotalol, and teach them that sweating may be the only warning sign of hypoglycemia.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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