Drug interactions
Insulin degludec-insulin aspart + Thyroid desiccated
Severity: Moderate
Insulin degludec-insulin aspart and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases glucose production and metabolic turnover, which can raise blood glucose in diabetes. Insulin needs may increase when thyroid replacement is started or the dose is raised.
What this interaction means in plain words
Insulin degludec-insulin aspart and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase gluconeogenesis, glycogen mobilization and insulin clearance, antagonizing insulin's effect.
What to do
Monitor blood glucose more frequently when starting or changing thyroid dosing. Adjust the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Thyroid desiccated?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases glucose production and metabolic turnover, which can raise blood glucose in diabetes. Insulin needs may increase when thyroid replacement is started or the dose is raised.
How serious is the interaction between Insulin degludec-insulin aspart and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing thyroid dosing. Adjust the insulin dose accordingly.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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