Drug interactions
Insulin degludec-liraglutide + Lurasidone
Severity: Moderate
Insulin degludec-liraglutide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can affect glucose metabolism and may worsen glycemic control. Lurasidone has a relatively low metabolic liability, but glucose control may still need review in diabetic patients.
What this interaction means in plain words
Insulin degludec-liraglutide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related changes in insulin sensitivity and secretion can cause hyperglycemia that opposes antidiabetic therapy.
What to do
Monitor fasting glucose and HbA1c after starting lurasidone and increase the antidiabetic dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Insulin degludec-liraglutide with Lurasidone?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can affect glucose metabolism and may worsen glycemic control. Lurasidone has a relatively low metabolic liability, but glucose control may still need review in diabetic patients.
How serious is the interaction between Insulin degludec-liraglutide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting lurasidone and increase the antidiabetic dose if hyperglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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