Drug interactions
Insulin degludec-liraglutide + Paliperidone
Severity: Moderate
Insulin degludec-liraglutide and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics, including paliperidone, can cause hyperglycemia and worsen diabetes control. Glycemic control with insulin degludec and liraglutide may need re-evaluation.
What this interaction means in plain words
Insulin degludec-liraglutide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Paliperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and altered insulin secretion oppose antidiabetic therapy.
What to do
Monitor glucose and HbA1c after starting paliperidone and increase antidiabetic doses if hyperglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Paliperidone?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics, including paliperidone, can cause hyperglycemia and worsen diabetes control. Glycemic control with insulin degludec and liraglutide may need re-evaluation.
How serious is the interaction between Insulin degludec-liraglutide and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting paliperidone and increase antidiabetic doses if hyperglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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