Drug interactions
Insulin degludec-liraglutide + Perphenazine
Severity: Moderate
Insulin degludec-liraglutide and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as perphenazine can impair glucose tolerance and raise blood glucose, which may reduce the effect of insulin degludec-liraglutide. Glycemic control may worsen after the antipsychotic is started or its dose is raised.
What this interaction means in plain words
Insulin degludec-liraglutide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Phenothiazines can reduce insulin sensitivity and secretion, producing a pharmacodynamic opposition to antidiabetic therapy.
What to do
Monitor blood glucose and HbA1c after starting or changing perphenazine. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Perphenazine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as perphenazine can impair glucose tolerance and raise blood glucose, which may reduce the effect of insulin degludec-liraglutide. Glycemic control may worsen after the antipsychotic is started or its dose is raised.
How serious is the interaction between Insulin degludec-liraglutide and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing perphenazine. Adjust the antidiabetic regimen as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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