Drug interactions
Insulin detemir + Linagliptin
Severity: Moderate
Insulin detemir and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin enhances glucose lowering and may raise hypoglycemia risk.
What this interaction means in plain words
Insulin detemir and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive effect of DPP-4 inhibition-enhanced incretin activity and exogenous insulin.
What to do
Monitor glucose after starting linagliptin and consider reducing the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin detemir with Linagliptin?
MediHelp rates the interaction as moderate. Insulin detemir and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to insulin enhances glucose lowering and may raise hypoglycemia risk.
How serious is the interaction between Insulin detemir and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose after starting linagliptin and consider reducing the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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