Drug interactions
Insulin detemir + Lixisenatide
Severity: Moderate
Insulin detemir and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide used with basal insulin increases the chance of hypoglycemia. A lower basal insulin dose is often needed when starting the combination.
What this interaction means in plain words
Insulin detemir and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Lixisenatide enhances glucose-dependent insulin secretion and slows gastric emptying, adding to the exogenous insulin effect.
What to do
Consider reducing the basal insulin dose when starting lixisenatide and monitor blood glucose frequently, titrating insulin to targets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Lixisenatide
Frequently asked questions
Can I take Insulin detemir with Lixisenatide?
MediHelp rates the interaction as moderate. Insulin detemir and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide used with basal insulin increases the chance of hypoglycemia. A lower basal insulin dose is often needed when starting the combination.
How serious is the interaction between Insulin detemir and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the basal insulin dose when starting lixisenatide and monitor blood glucose frequently, titrating insulin to targets.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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