Drug interactions
Insulin detemir + Lopinavir
Severity: Moderate
Insulin detemir and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir-based regimens can cause insulin resistance and hyperglycemia, which may weaken the glucose-lowering effect of insulin detemir. Patients with diabetes may need higher insulin doses after starting the antiretroviral.
What this interaction means in plain words
Insulin detemir and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce peripheral insulin resistance and impair glucose uptake, opposing insulin action.
What to do
Monitor blood glucose closely when starting or stopping lopinavir and titrate insulin detemir as needed. Reassess the dose again if the antiretroviral regimen changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin detemir with Lopinavir?
MediHelp rates the interaction as moderate. Insulin detemir and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir-based regimens can cause insulin resistance and hyperglycemia, which may weaken the glucose-lowering effect of insulin detemir. Patients with diabetes may need higher insulin doses after starting the antiretroviral.
How serious is the interaction between Insulin detemir and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping lopinavir and titrate insulin detemir as needed. Reassess the dose again if the antiretroviral regimen changes.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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