Drug interactions
Insulin glargine + Isocarboxazid
Severity: Moderate
Insulin glargine and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors can enhance the glucose-lowering effect of insulin and may increase the frequency or severity of hypoglycemia. Hypoglycemia may be more difficult to recognize or manage in a patient on an MAOI.
What this interaction means in plain words
Insulin glargine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAOIs may augment insulin secretion or sensitivity and impair counter-regulatory responses, producing additive hypoglycemia; the exact mechanism is not fully established.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the MAOI dose. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Isocarboxazid?
MediHelp rates the interaction as moderate. Insulin glargine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors can enhance the glucose-lowering effect of insulin and may increase the frequency or severity of hypoglycemia. Hypoglycemia may be more difficult to recognize or manage in a patient on an MAOI.
How serious is the interaction between Insulin glargine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the MAOI dose. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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