Drug interactions
Insulin glargine + Metformin-repaglinide
Severity: Moderate
Insulin glargine and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding insulin glargine to metformin and repaglinide increases the glucose-lowering effect of the regimen. Hypoglycemia is more likely, especially with the insulin secretagogue repaglinide, when doses are not reduced or meals are delayed.
What this interaction means in plain words
Insulin glargine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects from exogenous insulin, endogenous insulin secretion stimulated by repaglinide, and reduced hepatic glucose output from metformin.
What to do
Monitor blood glucose closely when starting, adjusting or stopping any component, and reduce the insulin or repaglinide dose if hypoglycemia occurs. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Insulin glargine
Frequently asked questions
Can I take Insulin glargine with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Insulin glargine and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding insulin glargine to metformin and repaglinide increases the glucose-lowering effect of the regimen. Hypoglycemia is more likely, especially with the insulin secretagogue repaglinide, when doses are not reduced or meals are delayed.
How serious is the interaction between Insulin glargine and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, adjusting or stopping any component, and reduce the insulin or repaglinide dose if hypoglycemia occurs. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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