Drug interactions
Insulin glargine + Nateglinide
Severity: Moderate
Insulin glargine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide with insulin glargine produces additive glucose lowering and increases hypoglycemia risk, mainly after meals.
What this interaction means in plain words
Insulin glargine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive effect of exogenous insulin and meglitinide-stimulated pancreatic insulin secretion.
What to do
Monitor glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin glargine with Nateglinide?
MediHelp rates the interaction as moderate. Insulin glargine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide with insulin glargine produces additive glucose lowering and increases hypoglycemia risk, mainly after meals.
How serious is the interaction between Insulin glargine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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