Drug interactions
Insulin glargine + Pasireotide
Severity: Moderate
Insulin glargine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia and can worsen diabetes control, so insulin requirements may rise. Glucose elevations can be significant.
What this interaction means in plain words
Insulin glargine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin and incretin (GLP-1, GIP) secretion more than it suppresses glucagon, raising glucose.
What to do
Monitor glucose frequently after starting pasireotide and intensify insulin glargine therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin glargine with Pasireotide?
MediHelp rates the interaction as moderate. Insulin glargine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide frequently causes hyperglycemia and can worsen diabetes control, so insulin requirements may rise. Glucose elevations can be significant.
How serious is the interaction between Insulin glargine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently after starting pasireotide and intensify insulin glargine therapy as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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