Drug interactions
Insulin glargine-lixisenatide + Moxifloxacin
Severity: Moderate
Insulin glargine-lixisenatide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs. Moxifloxacin is thought to carry a lower risk than some other quinolones but the effect can still occur.
What this interaction means in plain words
Insulin glargine-lixisenatide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell potassium channel function, causing insulin release and dysglycemia.
What to do
Monitor blood glucose during moxifloxacin therapy and adjust antidiabetic doses as needed. Switch antibiotic class if dysglycemia is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Moxifloxacin?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients on antidiabetic drugs. Moxifloxacin is thought to carry a lower risk than some other quinolones but the effect can still occur.
How serious is the interaction between Insulin glargine-lixisenatide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during moxifloxacin therapy and adjust antidiabetic doses as needed. Switch antibiotic class if dysglycemia is significant.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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