Drug interactions
Insulin glargine-lixisenatide + Paliperidone
Severity: Moderate
Insulin glargine-lixisenatide and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone, an atypical antipsychotic, can cause weight gain and hyperglycemia, which may reduce the effectiveness of insulin glargine and lixisenatide. Glucose control may worsen after it is started.
What this interaction means in plain words
Insulin glargine-lixisenatide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Paliperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and metabolic effects.
What to do
Monitor blood glucose and HbA1c after starting or changing paliperidone. Adjust the insulin glargine dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Paliperidone?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone, an atypical antipsychotic, can cause weight gain and hyperglycemia, which may reduce the effectiveness of insulin glargine and lixisenatide. Glucose control may worsen after it is started.
How serious is the interaction between Insulin glargine-lixisenatide and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing paliperidone. Adjust the insulin glargine dose as required.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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