Drug interactions
Insulin glargine-lixisenatide + Rosiglitazone
Severity: Major
Insulin glargine-lixisenatide and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone adds to the glucose-lowering effect of insulin and lixisenatide, increasing hypoglycemia risk. Combined with insulin it also raises the risk of edema, heart failure and possibly ischemic cardiac events.
What this interaction means in plain words
Insulin glargine-lixisenatide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glargine-lixisenatide belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin sensitization plus exogenous insulin, with thiazolidinedione and insulin-related renal fluid retention.
What to do
Avoid the combination where possible, particularly in patients with heart failure or cardiovascular disease. If used, monitor for edema, weight gain and hypoglycemia, and reduce the insulin dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Rosiglitazone?
MediHelp rates the interaction as major. Insulin glargine-lixisenatide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone adds to the glucose-lowering effect of insulin and lixisenatide, increasing hypoglycemia risk. Combined with insulin it also raises the risk of edema, heart failure and possibly ischemic cardiac events.
How serious is the interaction between Insulin glargine-lixisenatide and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in patients with heart failure or cardiovascular disease. If used, monitor for edema, weight gain and hypoglycemia, and reduce the insulin dose as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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