Drug interactions
Insulin glargine-lixisenatide + Saxagliptin
Severity: Moderate
Insulin glargine-lixisenatide and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding saxagliptin to insulin and lixisenatide gives additive glucose lowering and may raise the risk of hypoglycemia. Lixisenatide and DPP-4 inhibitors also act on the same incretin pathway, so the combination offers little added benefit.
What this interaction means in plain words
Insulin glargine-lixisenatide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on incretin pathways and glucose lowering alongside insulin.
What to do
Avoid combining a DPP-4 inhibitor with a GLP-1 receptor agonist. If saxagliptin is used, monitor glucose and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Saxagliptin?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding saxagliptin to insulin and lixisenatide gives additive glucose lowering and may raise the risk of hypoglycemia. Lixisenatide and DPP-4 inhibitors also act on the same incretin pathway, so the combination offers little added benefit.
How serious is the interaction between Insulin glargine-lixisenatide and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining a DPP-4 inhibitor with a GLP-1 receptor agonist. If saxagliptin is used, monitor glucose and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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