Drug interactions
Insulin glulisine + Liraglutide
Severity: Moderate
Insulin glulisine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. Liraglutide may also reduce appetite and delay gastric emptying, changing insulin requirements.
What this interaction means in plain words
Insulin glulisine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering via GLP-1 receptor-mediated glucose-dependent insulin secretion, glucagon suppression and delayed gastric emptying.
What to do
Consider reducing the insulin dose when starting liraglutide and monitor glucose frequently. Do not mix the two in the same injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin glulisine with Liraglutide?
MediHelp rates the interaction as moderate. Insulin glulisine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide with insulin enhances glucose lowering and raises the risk of hypoglycemia. Liraglutide may also reduce appetite and delay gastric emptying, changing insulin requirements.
How serious is the interaction between Insulin glulisine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting liraglutide and monitor glucose frequently. Do not mix the two in the same injection.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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