Drug interactions
Insulin inhaled + Linagliptin
Severity: Moderate
Insulin inhaled and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to prandial inhaled insulin increases glucose lowering and the chance of hypoglycemia. The combination is acceptable but typically needs dose review.
What this interaction means in plain words
Insulin inhaled and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from DPP-4 inhibition and exogenous insulin.
What to do
Monitor blood glucose and reduce the inhaled insulin dose if hypoglycemia occurs after linagliptin is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin inhaled with Linagliptin?
MediHelp rates the interaction as moderate. Insulin inhaled and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin added to prandial inhaled insulin increases glucose lowering and the chance of hypoglycemia. The combination is acceptable but typically needs dose review.
How serious is the interaction between Insulin inhaled and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the inhaled insulin dose if hypoglycemia occurs after linagliptin is started.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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