Drug interactions
Insulin inhaled + Sotalol
Severity: Moderate
Insulin inhaled and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol can hide the adrenergic warning signs of hypoglycemia and delay recovery from it, and can alter glucose control in patients using inhaled insulin.
What this interaction means in plain words
Insulin inhaled and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-blockade blunts adrenergic hypoglycemia symptoms and impairs glycogenolysis.
What to do
Monitor blood glucose more frequently when sotalol is started or changed, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Insulin inhaled with Sotalol?
MediHelp rates the interaction as moderate. Insulin inhaled and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol can hide the adrenergic warning signs of hypoglycemia and delay recovery from it, and can alter glucose control in patients using inhaled insulin.
How serious is the interaction between Insulin inhaled and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when sotalol is started or changed, and adjust the insulin dose as needed.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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