Drug interactions
Insulin isophane protamine human + Liraglutide
Severity: Moderate
Insulin isophane protamine human and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide combined with insulin lowers glucose more than either alone and raises hypoglycemia risk. Insulin doses can often be reduced once liraglutide is established.
What this interaction means in plain words
Insulin isophane protamine human and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering via GLP-1 receptor-mediated glucose-dependent insulin secretion and glucagon suppression plus exogenous insulin.
What to do
Consider reducing the insulin dose at liraglutide initiation and monitor glucose frequently, titrating insulin to readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Liraglutide
Frequently asked questions
Can I take Insulin isophane protamine human with Liraglutide?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide combined with insulin lowers glucose more than either alone and raises hypoglycemia risk. Insulin doses can often be reduced once liraglutide is established.
How serious is the interaction between Insulin isophane protamine human and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose at liraglutide initiation and monitor glucose frequently, titrating insulin to readings.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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