Drug interactions
Insulin isophane protamine human + Saxagliptin
Severity: Moderate
Insulin isophane protamine human and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a DPP-4 inhibitor to NPH insulin improves glycemic control but raises the chance of hypoglycemia. The risk is greatest when insulin doses were previously set without the gliptin.
What this interaction means in plain words
Insulin isophane protamine human and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Saxagliptin belongs to Endocrine.
Why it happens
Additive glucose-lowering through insulin supply plus increased incretin-mediated glucose-dependent insulin secretion and reduced glucagon.
What to do
Monitor blood glucose when starting or stopping saxagliptin and consider reducing the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Saxagliptin?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a DPP-4 inhibitor to NPH insulin improves glycemic control but raises the chance of hypoglycemia. The risk is greatest when insulin doses were previously set without the gliptin.
How serious is the interaction between Insulin isophane protamine human and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping saxagliptin and consider reducing the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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