Drug interactions
Insulin lispro + Linagliptin
Severity: Moderate
Insulin lispro and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin adds to the glucose-lowering effect of insulin and can increase the risk of hypoglycemia. The risk is modest because DPP-4 inhibition acts in a glucose-dependent way.
What this interaction means in plain words
Insulin lispro and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering through DPP-4 inhibition raising incretin levels together with exogenous insulin.
What to do
Monitor blood glucose after starting linagliptin and consider a lower insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin lispro with Linagliptin?
MediHelp rates the interaction as moderate. Insulin lispro and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linagliptin adds to the glucose-lowering effect of insulin and can increase the risk of hypoglycemia. The risk is modest because DPP-4 inhibition acts in a glucose-dependent way.
How serious is the interaction between Insulin lispro and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting linagliptin and consider a lower insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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