Drug interactions
Insulin lispro + Lopinavir
Severity: Moderate
Insulin lispro and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia. Patients on insulin may need higher doses to maintain glycemic control.
What this interaction means in plain words
Insulin lispro and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake (GLUT4 inhibition) and promote insulin resistance.
What to do
Monitor blood glucose when starting or stopping lopinavir/ritonavir and titrate the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin lispro with Lopinavir?
MediHelp rates the interaction as moderate. Insulin lispro and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors can cause insulin resistance and hyperglycemia. Patients on insulin may need higher doses to maintain glycemic control.
How serious is the interaction between Insulin lispro and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lopinavir/ritonavir and titrate the insulin dose accordingly.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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