Drug interactions
Insulin lispro + Pegvisomant
Severity: Moderate
Insulin lispro and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, which lowers IGF-1 and improves insulin sensitivity in acromegaly. Patients on insulin may therefore develop hypoglycemia and need less insulin.
What this interaction means in plain words
Insulin lispro and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism removes GH-mediated insulin resistance, producing additive glucose lowering with insulin.
What to do
Monitor blood glucose closely after starting pegvisomant and reduce the insulin lispro dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Insulin lispro with Pegvisomant?
MediHelp rates the interaction as moderate. Insulin lispro and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action, which lowers IGF-1 and improves insulin sensitivity in acromegaly. Patients on insulin may therefore develop hypoglycemia and need less insulin.
How serious is the interaction between Insulin lispro and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting pegvisomant and reduce the insulin lispro dose as needed.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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