Drug interactions
Insulin neutral human + Lopinavir
Severity: Moderate
Insulin neutral human and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir can cause insulin resistance and hyperglycemia. In people using insulin, glucose control may deteriorate and higher doses may be required.
What this interaction means in plain words
Insulin neutral human and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitors impair insulin signaling and glucose uptake, causing peripheral insulin resistance.
What to do
Monitor blood glucose more often when starting or stopping lopinavir/ritonavir. Titrate insulin doses to the glucose results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Insulin neutral human with Lopinavir?
MediHelp rates the interaction as moderate. Insulin neutral human and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted lopinavir can cause insulin resistance and hyperglycemia. In people using insulin, glucose control may deteriorate and higher doses may be required.
How serious is the interaction between Insulin neutral human and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or stopping lopinavir/ritonavir. Titrate insulin doses to the glucose results.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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