Drug interactions
Insulin neutral human-insulin isophane protamine human + Linagliptin
Severity: Minor
Insulin neutral human-insulin isophane protamine human and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin added to insulin improves glycemic control but may modestly increase hypoglycemia risk. The risk is lower than with sulfonylureas.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering from DPP-4 inhibition, which raises incretin levels, plus exogenous insulin.
What to do
Monitor glucose and reduce the insulin dose if hypoglycemia occurs after linagliptin is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Linagliptin?
MediHelp rates the interaction as minor. Insulin neutral human-insulin isophane protamine human and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linagliptin added to insulin improves glycemic control but may modestly increase hypoglycemia risk. The risk is lower than with sulfonylureas.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and reduce the insulin dose if hypoglycemia occurs after linagliptin is started.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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