Drug interactions
Insulin neutral human-insulin isophane protamine human + Miglitol
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Miglitol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miglitol lowers postprandial glucose and adds to insulin effect, raising hypoglycemia risk. Because miglitol blocks carbohydrate digestion, treating hypoglycemia with sucrose or starch is ineffective.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Miglitol belongs to Endocrine.
Why it happens
Additive glucose lowering; miglitol inhibits intestinal alpha-glucosidase and delays carbohydrate absorption.
What to do
Treat hypoglycemia with oral glucose (dextrose) or glucagon rather than sucrose. Monitor glucose and adjust the insulin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Miglitol
- Miglitol + Pramlintide Major
- Aripiprazole + Miglitol Moderate
- Asenapine + Miglitol Moderate
- Chlorthalidone + Miglitol Moderate
- Clozapine + Miglitol Moderate
- Cortisone + Miglitol Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Miglitol?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Miglitol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miglitol lowers postprandial glucose and adds to insulin effect, raising hypoglycemia risk. Because miglitol blocks carbohydrate digestion, treating hypoglycemia with sucrose or starch is ineffective.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Miglitol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Treat hypoglycemia with oral glucose (dextrose) or glucagon rather than sucrose. Monitor glucose and adjust the insulin dose.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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